Document Detail


Model systems for experimental studies: retinal ganglion cells in culture.
MedLine Citation:
PMID:  18929116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glaucomatous optic neuropathy is the most common optic nerve disease. The mechanisms by which retinal ganglion cells (RGCs) die in glaucoma are becoming better understood, but are still poorly defined. Elucidating the pathways that connect risk factors for glaucoma (e.g., elevated intraocular pressure) and RGC death is difficult in patients because of ethical and practical constraints. Even in experimental animals, single-cell observations and cell-cell interactions can be tricky to tease apart. For these reasons, it is helpful to use cell and tissue culture models for studying RGCs and other cellular constituents of the optic nerve. This chapter describes the advantages and disadvantages of several commonly used methods for preparing and studying these cultures, including those most relevant to glaucomatous optic neuropathy.
Authors:
Emilie Goodyear; Leonard A Levin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in brain research     Volume:  173     ISSN:  1875-7855     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, University of Montreal, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Culture Techniques
Cell Differentiation
Cells, Cultured
Humans
Mice
Models, Biological*
Retinal Ganglion Cells* / cytology,  physiology

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