| Model systems for experimental studies: retinal ganglion cells in culture. | |
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MedLine Citation:
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PMID: 18929116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glaucomatous optic neuropathy is the most common optic nerve disease. The mechanisms by which retinal ganglion cells (RGCs) die in glaucoma are becoming better understood, but are still poorly defined. Elucidating the pathways that connect risk factors for glaucoma (e.g., elevated intraocular pressure) and RGC death is difficult in patients because of ethical and practical constraints. Even in experimental animals, single-cell observations and cell-cell interactions can be tricky to tease apart. For these reasons, it is helpful to use cell and tissue culture models for studying RGCs and other cellular constituents of the optic nerve. This chapter describes the advantages and disadvantages of several commonly used methods for preparing and studying these cultures, including those most relevant to glaucomatous optic neuropathy. |
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Authors:
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Emilie Goodyear; Leonard A Levin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Progress in brain research Volume: 173 ISSN: 1875-7855 ISO Abbreviation: Prog. Brain Res. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376441 Medline TA: Prog Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 279-84 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Montreal, Montreal, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Culture Techniques Cell Differentiation Cells, Cultured Humans Mice Models, Biological* Retinal Ganglion Cells* / cytology, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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