Document Detail

Model systems of epithelium-mesenchyme transitions.
MedLine Citation:
PMID:  9124039     Owner:  NLM     Status:  MEDLINE    
This contribution discusses which factors bring about the transformation of epithelium to mesenchyme. Amongst biological agents which have this role are a number of cytokines (e.g. EGF, FGF-1, TGF-beta, HGF/SF) and extracellular matrix macromolecules, such as collagens. The coordinated changes in cell morphology, associated with the induction of cell motility and the loss of inter-cellular junctions, are under the control of signaling molecules that transduce the signal emanating from the plasma membrane, which ultimately lead to changes in gene expression.
B Boyer; A M Vallés; J P Thiery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta anatomica     Volume:  156     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1996  
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  227-39     Citation Subset:  IM    
Laboratoire de Dynamique et Compartimentation Cellulaires, UMR CNRS 144, Institut Curie Section de Recherche, Paris, France.
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MeSH Terms
Cell Movement
Epithelium / physiology
Extracellular Matrix / physiology
Gap Junctions / physiology
Gene Expression Regulation, Developmental
Growth Substances / physiology
Mesoderm / physiology*
Models, Biological
Signal Transduction
Reg. No./Substance:
0/Growth Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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