| Model systems for activation of nucleic acid encoded prodrugs. | |
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MedLine Citation:
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PMID: 17436260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of more selective chemotherapeutic agents for benign treatments of malicious diseases is highly desirable. In recent years model systems for the release of small molecule drugs from nucleic acid conjugates by templated chemical or photochemical reactions have been designed. Common for these systems is that the stoichiometric or catalytic drug release is controlled by the highly selective hybridization between complementary strands of nucleic acids. Herein, the concepts of the new field of nucleic acid templated release reactions are outlined. |
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Authors:
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Mikkel F Jacobsen; Emiliano Cló; Andriy Mokhir; Kurt V Gothelf |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: ChemMedChem Volume: 2 ISSN: 1860-7187 ISO Abbreviation: - Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2008-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259013 Medline TA: ChemMedChem Country: Germany |
Other Details:
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Languages: eng Pagination: 793-9 Citation Subset: IM |
Affiliation:
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Centre for DNA Nanotechnology, Center for Catalysis and Interdisciplinary Nanoscience Center (iNANO), Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Drug Delivery Systems / methods, trends Humans Models, Chemical* Nucleic Acids / chemistry*, genetics, metabolism* Photochemistry / methods Prodrugs / chemistry*, metabolism* Singlet Oxygen / chemistry Templates, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Prodrugs; 17778-80-2/Singlet Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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