Document Detail

Model study of time-dependent muscle response to pulsed electrical stimulation.
MedLine Citation:
PMID:  20082335     Owner:  NLM     Status:  In-Process    
A systems-level model analysis of neuromuscular response to external electrical stimulation is presented. Action potential (AP) generation, dynamics of voltage-based calcium release at the motor endplates controlled by the arrival of APs, and muscle force production are all comprehensively included. Numerical predictions exhibit trends that are qualitatively similar to measurements of muscle response in rats from a burst of cortical stimulation and a nanosecond impulse. Modulation of neural membrane conductances (including possible electroporation) that alters the neural impulse generation frequency is hypothesized as a possible mechanism leading to observed changes in muscle force production. Other possibilities such as calcium release at nerve end endings also exist. It is also proposed that multipulsing strategies and changing the electric field direction by using multielectrode systems would be useful.
Ravindra P Joshi; Ashutosh Mishra; Shu Xiao; Anderi Pakhomov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioelectromagnetics     Volume:  31     ISSN:  1521-186X     ISO Abbreviation:  Bioelectromagnetics     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008281     Medline TA:  Bioelectromagnetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-70     Citation Subset:  IM    
Copyright Information:
2010 Wiley-Liss, Inc.
Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, USA.
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