Document Detail

Model study of the effects of interactions between systemic and peripheral circulation on interstitial fluid balance.
MedLine Citation:
PMID:  18372695     Owner:  NLM     Status:  MEDLINE    
Interstitial fluid balance is severely altered in microgravity, but the mechanisms underlying the fluid shift from lower to upper body are still partially unclear. A lumped parameter model of the arterial tree with active and non linear modulation of peripheral resistances and capillary fluid exchange was adopted to simulate the response of microcirculation to pulsatility and edema. Results suggest that myogenic regulation not only impinges on arteriolar radius, but it also indirectly affects interstitial fluid balance. Non linear dynamics of blood pressure (BP) and flow in capillary beds are influenced by systemic pulsatility, hinting that local activity is involved in the response to peripheral edema as well.
Federico Aletti; Giuseppe Baselli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology     Volume:  14     ISSN:  1077-9248     ISO Abbreviation:  J Gravit Physiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437868     Medline TA:  J Gravit Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  P51-2     Citation Subset:  IM    
Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci, 32-20133 Milano, Italy.
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MeSH Terms
Arteries / physiopathology
Blood Pressure
Capillaries / physiopathology
Capillary Permeability
Computer Simulation
Dizziness / etiology*,  metabolism,  physiopathology
Edema / etiology*,  metabolism,  physiopathology
Extracellular Fluid / metabolism*
Models, Cardiovascular*
Pulsatile Flow
Regional Blood Flow
Space Flight
Time Factors
Vascular Resistance
Water-Electrolyte Balance*
Weightlessness / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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