Document Detail


Model studies of perinatal insults: a comprehensive approach to behavioural teratology.
MedLine Citation:
PMID:  2941779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The perinatal brain provides a vulnerable target for many noxious insults that interfere--according to their intensity, specificity and timing--with morphogenetic (cell proliferation, migration, association and programmed cell death) and functiogenetic (axogenesis, dendrogenesis, synaptogenesis and myelination) processes. The disturbance of brain cells and/or disorganization of their connections give rise to structural, biochemical and functional pathology most frequently detected in the form of behavioural deviations. For the study of behavioural teratogenicity of perinatal malnutrition, protein synthesis alteration and glucocorticoid administration--all being also important clinically--metabolic, cytotoxic and receptor-mediated models have been designed. The longitudinal follow--up of morphological, neurochemical, endocrine, reproductive, and behavioural changes proved to be valuable for the elucidation of pathogenetic mechanisms as well as for the evaluation of pharmacological influences preventing maldevelopment of the brain.
Authors:
A Pavlík; O Benesová; M Buresová
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  34 Suppl     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1985  
Date Detail:
Created Date:  1986-07-31     Completed Date:  1986-07-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Behavior, Animal*
Dexamethasone / pharmacology
Disease Models, Animal
Mental Disorders / etiology*
Nutrition Disorders / complications
Rats
Receptors, Glucocorticoid / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Receptors, Glucocorticoid; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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