Document Detail

Model-specific selection of molecular targets for heart failure gene therapy.
MedLine Citation:
PMID:  21954055     Owner:  NLM     Status:  MEDLINE    
Heart failure (HF) is a complex multifaceted problem of abnormal ventricular function and structure. In recent years, new information has been accumulated allowing for a more detailed understanding of the cellular and molecular alterations that are the underpinnings of diverse causes of HF, including myocardial ischemia, pressure-overload, volume-overload or intrinsic cardiomyopathy. Modern pharmacological approaches to treat HF have had a significant impact on the course of the disease, although they do not reverse the underlying pathological state of the heart. Therefore gene-based therapy holds a great potential as a targeted treatment for cardiovascular diseases. Here, we survey the relative therapeutic efficacy of genetic modulation of β-adrenergic receptor signaling, Ca(2+) handling proteins and angiogenesis in the most common extrinsic models of HF.
Michael G Katz; Anthony S Fargnoli; Catherine E Tomasulo; Louella A Pritchette; Charles R Bridges
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The journal of gene medicine     Volume:  13     ISSN:  1521-2254     ISO Abbreviation:  J Gene Med     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-25     Completed Date:  2012-02-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9815764     Medline TA:  J Gene Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  573-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Department of Surgery, Division of Cardiovascular Surgery, The University of Pennsylvania Medical Center, Philadelphia, PA, USA.
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MeSH Terms
Disease Models, Animal
Genetic Therapy / methods*
Heart / physiopathology*
Heart Failure / genetics*,  physiopathology,  therapy*
Myocardial Ischemia / genetics,  physiopathology,  therapy
Receptors, Adrenergic, beta / genetics,  metabolism
Signal Transduction / physiology
Grant Support
1-R01-HL083078-01A2/HL/NHLBI NIH HHS; P30-DK047757/DK/NIDDK NIH HHS; R01 HL083078/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Receptors, Adrenergic, beta

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