Document Detail

Model prediction of subendocardial perfusion of the coronary circulation in the presence of an epicardial coronary artery stenosis.
MedLine Citation:
PMID:  18273659     Owner:  NLM     Status:  MEDLINE    
The subendocardium is most vulnerable to ischemia, which is ameliorated by relaxation during diastole and increased coronary pressure. Recent clinical techniques permit the measuring of subendocardial perfusion and it is therefore important to gain insight into how measurements depend on perfusion conditions of the heart. Using data from microsphere experiments a layered model of the myocardial wall was developed. Myocardial perfusion distribution during hyperemia was predicted for different degrees of coronary stenosis and at different levels of Diastolic Time Fraction (DTF). At the reference DTF, perfusion was rather evenly distributed over the layers and the effect of the stenosis was homogenous. However, at shorter or longer DTF, the subendocardium was the first or last to suffer from shortage of perfusion. It is therefore concluded that the possible occurrence of subendocardial ischemia at exercise is underestimated when heart rate is increased and DTF is lower.
Jeroen P H M van den Wijngaard; Christina Kolyva; Maria Siebes; Jenny Dankelman; Martin J C van Gemert; Jan J Piek; Jos A E Spaan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  46     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-09-05     Completed Date:  2008-09-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-32     Citation Subset:  IM    
Department of Medical Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Coronary Circulation / physiology*
Coronary Stenosis / physiopathology*
Endocardium / physiopathology*
Models, Cardiovascular*
Regional Blood Flow

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