| Model-free arterial spin labelling for cerebral blood flow quantification: introduction of regional arterial input functions identified by factor analysis. | |
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MedLine Citation:
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PMID: 18060721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To identify regional arterial input functions (AIFs) using factor analysis of dynamic studies (FADS) when quantification of perfusion is performed using model-free arterial spin labelling. MATERIAL AND METHODS: Five healthy volunteers and one patient were examined on a 3-T Philips unit using quantitative STAR labelling of arterial regions (QUASAR). Two sets of images were retrieved, one where the arterial signal had been crushed and another where it was retained. FADS was applied to the arterial signal curves to acquire the AIFs. Perfusion maps were obtained using block-circulant SVD deconvolution and regional AIFs obtained by FADS. In the volunteers, the ASL experiment was repeated within 24 h. The patient was also examined using dynamic susceptibility contrast MRI. RESULTS: In the healthy volunteers, CBF was 64+/-10 ml/[min 100 g] (mean+/-S.D.) in GM and 24+/-4 ml/[min 100 g] in WM, while the mean aBV was 0.94% in GM and 0.25% in WM. DISCUSSION: Good CBF image quality and reasonable quantitative CBF values were obtained using the combined QUASAR/FADS technique. We conclude that FADS may be a useful supplement in the evaluation of ASL data using QUASAR. |
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Authors:
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Linda Knutsson; Karin Markenroth Bloch; Stig Holtås; Ronnie Wirestam; Freddy Ståhlberg |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-03 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 26 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 554-9 Citation Subset: IM |
Affiliation:
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Center for Medical Imaging and Physiology, MR Division, Lund University Hospital, SE-221 85 Lund, Sweden. linda.knutsson@med.lu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Arteries / pathology* Blood Volume Brain / pathology Brain Neoplasms / diagnosis, pathology* Cerebrovascular Circulation* Computer Simulation Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Middle Aged Perfusion Regional Blood Flow / physiology Spin Labels |
| Chemical | |
Reg. No./Substance:
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0/Spin Labels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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