| Model of extensive and severe tracheal stenosis in dogs. | |
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MedLine Citation:
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PMID: 19030747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To create an animal model of extensive longitudinal tracheal stenosis (TS) that can be useful to test different surgical techniques of tracheal reconstruction. METHODS: Twenty male mongrel dogs were submitted to standard TS and randomly distributed to observation for 3 weeks (n=10) or 6 weeks (n=10). Under general anesthesia, an elliptical area (major axis from 1st to 20th ring and minor axis 40% of tracheal diameter) was resected and the stumps were sutured. The internal and external diameters were measured (before and after the observation time) and the stenosis index was calculated. Blood samples were collected (gasometry, hematocrit and hemoglobin.) before and after the surgical proceedings. RESULTS: The weight was significant lower in the animals of 6 weeks (15,551+/-3286.2) in comparison with those of 3 weeks observation (17,250+/-3575.0). No significant differences were noted in the extension of the trachea on the 21st day (21.2+/- 1.8) or 42nd day (21.1+/-1.7). The mean (40.1) and the median (40.5) of rings counted on the 21st day were quite similar to mean (38.1) and median (39.0) that were counted on the 42nd day. In the animals of group A (3 weeks) the mean (46.8%) and the median (49.8%) of index stenosis showed no significant difference (Mann Whitney test p<0.001) in comparison with the mean (55.1%) and median (52.4%) of the animals from group B (6 weeks). No mechanical or biochemical distresses were recorded through all period of observation. CONCLUSION: The surgical proceeding was effective to promote a model of longitudinal and extensive tracheal stenosis. |
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Authors:
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Jairo Vaidergorn; Djalma José Fagundes; Ana Lucia Machado; Rimarcs Gomes Ferreira; Yara Juliano; Neil Ferreira Novo; Paulo de Oliveira Gomes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 23 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
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Languages: eng Pagination: 497-500 Citation Subset: IM |
Affiliation:
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Cardio-Thoracic Surgery Division, Medicine School, Santo Amaro University, Sao Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Disease Models, Animal* Dogs Male Random Allocation Statistics, Nonparametric Trachea / injuries, pathology, surgery* Tracheal Stenosis / pathology, surgery* Tracheotomy / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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