Document Detail


Model of differential susceptibility to mucosal Burkholderia pseudomallei infection.
MedLine Citation:
PMID:  11796576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with protean clinical manifestations. The major route of infection is thought to be through subcutaneous inoculation of contaminated soil and water, although ingestion and inhalation of contaminated aerosols are also possible. This study examines infection through the intranasal route in a murine model to mimic infection through inhalation. Two strains of mice, C57BL/6 and BALB/c, exhibit differential susceptibilities to the infection, with the C57BL/6 mice being considerably more resistant. To examine host factors that could contribute to this difference, bacterial loads and cytokine profiles in the two strains of mice were compared. We found that infected BALB/c mice exhibited higher bacterial loads in the lung and spleen and that they produced significantly higher levels of gamma interferon (IFN-gamma) in the serum than C57BL/6 mice. Although tumor necrosis factor alpha and interleukin-1 could be detected in the nasal washes and sera of both strains of mice, the production in serum was transient and much lower than that of IFN-gamma. C57BL/6 mice also exhibited memory responses to bacteria upon reinfection, with the production of serum immunoglobulin G (IgG) and mucosal IgA antibodies. Thus, it is possible that the production of systemic and mucosal antibodies is important for protection against disease in C57BL/6 mice.
Authors:
Boping Liu; Ghee Chong Koo; Eu Hian Yap; Kim Lee Chua; Yunn-Hwen Gan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  70     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-02-21     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  504-11     Citation Subset:  IM    
Affiliation:
Department of Biochemistry. Department of Microbiology, National University of Singapore, Singapore 119260.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Animals
Antibodies, Bacterial / immunology
Burkholderia pseudomallei / immunology,  physiology
Cytokines / blood,  genetics
Disease Models, Animal
Female
Gene Expression
Immunity, Mucosal
Interferon-gamma / genetics
Liver / immunology
Lung / immunology
Melioidosis / blood,  immunology*,  microbiology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nasal Lavage Fluid / immunology
Nasal Mucosa / immunology*
Species Specificity
Spleen / immunology
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Cytokines; 82115-62-6/Interferon-gamma
Comments/Corrections

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