| Model-based studies of autonomic and metabolic dysfunction in sleep apnea. | |
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MedLine Citation:
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PMID: 20217365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity and insulin resistance are highly prevalent in subjects diagnosed with sleep apnea. One factor common to obesity, sleep and insulin resistance is autonomic nervous system dysfunction, in particular, sympathetic overactivity. Although the causal links among these factors are not well understood, it is likely that the vicious cycle of interplay among these factors predisposes to the emergence of "metabolic syndrome", a convergence of obesity, hypertension, insulin resistance and dyslipidemia that is appearing in epidemic proportions in the United States and other countries. This chapter provides an overview of the ongoing experimental and modeling studies in my laboratory aimed at elucidating and quantifying the relationships among autonomic dysfunction, insulin resistance and severity of sleep apnea in overweight subjects. These studies employ a "minimal modeling" approach to extract information characterizing autonomic function from noninvasive cardiorespiratory measurements. We subsequently determine the relationship of these model parameters to the parameters estimated from the Bergman minimal insulin-glucose model using data obtained from the frequently sampled intravenous glucose tolerance test performed on the same individuals. |
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Authors:
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Michael C K Khoo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 669 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-05-14 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Biomedical Engineering Department, University of Southern California, Los Angeles, CA, USA. khoo@bmsr.usc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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metabolism Adolescent Autonomic Nervous System / physiopathology* Child Female Humans Male Models, Biological* Respiration Sleep Apnea Syndromes / pathology, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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EB001978/EB/NIBIB NIH HHS; HL090451/HL/NHLBI NIH HHS; M01 RR00047/RR/NCRR NIH HHS; P41 EB001978-26/EB/NIBIB NIH HHS; R21 HL090451-03/HL/NHLBI NIH HHS; U54 CA 116848/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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