| Model-based imaging of cardiac apparent conductivity and local conduction velocity for diagnosis and planning of therapy. | |
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MedLine Citation:
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PMID: 18955178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present an adaptive algorithm which uses a fast electrophysiological (EP) model to estimate apparent electrical conductivity and local conduction velocity from noncontact mapping of the endocardial surface potential. Development of such functional imaging revealing hidden parameters of the heart can be instrumental for improved diagnosis and planning of therapy for cardiac arrhythmia and heart failure, for example during procedures such as radio-frequency ablation and cardiac resynchronisation therapy. The proposed model is validated on synthetic data and applied to clinical data derived using hybrid X-ray/magnetic resonance imaging. We demonstrate a qualitative match between the estimated conductivity parameter and pathology locations in the human left ventricle. We also present a proof of concept for an electrophysiological model which utilizes the estimated apparent conductivity parameter to simulate the effect of pacing different ventricular sites. This approach opens up possibilities to directly integrate modelling in the cardiac EP laboratory. |
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Authors:
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Phani Chinchapatnam; Kawal S Rhode; Matthew Ginks; C Aldo Rinaldi; Pier Lambiase; Reza Razavi; Simon Arridge; Maxime Sermesant |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: IEEE transactions on medical imaging Volume: 27 ISSN: 1558-254X ISO Abbreviation: IEEE Trans Med Imaging Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-02-06 Revised Date: 2012-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8310780 Medline TA: IEEE Trans Med Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1631-42 Citation Subset: IM |
Affiliation:
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Centre for Medical Image Computing, University College London, Gower Street, WC1E 6BT London, U.K. p.chinchapatnam@cs.ucl.AC.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Surface Potential Mapping
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methods Bundle-Branch Block / diagnosis, physiopathology, therapy Electric Conductivity / diagnostic use* Electrocardiography Electrophysiologic Techniques, Cardiac* Endocardium / physiopathology, radiography Heart Conduction System / physiology, radiography Humans Magnetic Resonance Imaging Mathematical Computing* Membrane Potentials Models, Cardiovascular* Myocardial Ischemia / diagnosis, physiopathology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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