| A model predictive control strategy toward optimal structured treatment interruptions in anti-HIV therapy. | |
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MedLine Citation:
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PMID: 20172797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this paper, model predictive control (MPC) strategies are applied to the control of human immunodeficiency virus infection, with the final goal of implementing an optimal structured treatment interruptions protocol. The MPC algorithms proposed in this paper use a dynamic model recently developed in order to mimic both transient responses and ultimate behavior, and to describe accordingly the different effect of commonly used drugs in highly active antiretroviral therapy (HAART). Simulation studies show that the proposed methods achieve the goal of reducing the drug consumption (thus minimizing the severe side effects of HAART drugs) while respecting the desired constraints on CD4+ cells and free virions concentration. Such promising results are obtained with realistic assumptions of infrequent (possibly noisy) measurements of a subset of model state variables. Furthermore, the control objectives are achieved even in the presence of mismatch between the dynamics of true patients and that of the MPC model. |
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Authors:
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Gabriele Pannocchia; Marco Laurino; Alberto Landi |
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Publication Detail:
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Type: Journal Article Date: 2010-02-17 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 57 ISSN: 1558-2531 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1040-50 Citation Subset: IM |
Affiliation:
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Dipartimento di Ingegneria Chimica, Chimica Industriale e Scienza dei Materiali, University of Pisa, Pisa, Italy. g.pannocchia@ing.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Anti-HIV Agents / administration & dosage* Anti-Retroviral Agents / administration & dosage* Antiretroviral Therapy, Highly Active / methods* Computer Simulation Drug Therapy, Computer-Assisted / methods* HIV Infections / diagnosis*, therapy* Humans Models, Biological* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Anti-Retroviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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