| A model of cerebrovascular reactivity including the circle of willis and cortical anastomoses. | |
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MedLine Citation:
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PMID: 20094916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrovascular pathologies are extremely complex, due to the multitude of factors acting simultaneously on cerebral hemodynamics. In this work, a mathematical model of cerebral hemodynamics and intracranial pressure (ICP) dynamics, developed in previous years, is extended to account for heterogeneity in cerebral blood flow. The model includes the Circle of Willis, six regional districts independently regulated by autoregulation and CO2 reactivity, distal cortical anastomoses, venous circulation, the cerebrospinal fluid circulation, and the ICP-volume relationship. Results agree with data in the literature and highlight the existence of a monotonic relationship between transient hyperemic response and the autoregulation gain. During unilateral internal carotid artery stenosis, local blood flow regulation is progressively lost in the ipsilateral territory with the presence of a steal phenomenon, while the anterior communicating artery plays the major role to redistribute the available blood flow. Conversely, distal collateral circulation plays a major role during unilateral occlusion of the middle cerebral artery. In conclusion, the model is able to reproduce several different pathological conditions characterized by heterogeneity in cerebrovascular hemodynamics and cannot only explain generalized results in terms of physiological mechanisms involved, but also, by individualizing parameters, may represent a valuable tool to help with difficult clinical decisions. |
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Authors:
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Mauro Ursino; Massimo Giannessi |
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Publication Detail:
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Type: Journal Article Date: 2010-01-22 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-18 Completed Date: 2010-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 955-74 Citation Subset: IM |
Affiliation:
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Department of Electronics, Computer Science, and Systems, University of Bologna, via Venezia 52, 47023, Cesena, FC, Italy. mauro.ursino@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriovenous Anastomosis
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physiopathology* Blood Flow Velocity Blood Pressure Cerebral Arteries / physiopathology* Cerebrovascular Circulation* Cerebrovascular Disorders / physiopathology* Circle of Willis / physiopathology* Computer Simulation Humans Models, Cardiovascular* Models, Neurological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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