Document Detail

Mode of vascularization of control and basic fibroblast growth factor-stimulated prefabricated skin flaps.
MedLine Citation:
PMID:  9529216     Owner:  NLM     Status:  MEDLINE    
This study, using 62 rabbits, examines the rate and pattern of vascular outgrowth from a subcutaneously implanted vascular pedicle, how the newly formed vessels connect to preexisting skin vessels, and whether local application of basic fibroblast growth factor can accelerate the angiogenic process. When the femoral artery and vein of rabbits are implanted beneath the skin, angiogenesis from both the pedicle and small blood vessels within the adjacent skin begins within 3 days. Perfusion with India ink reveals connections between the pedicle and dermal vessels as early as 5 days after implantation of the pedicle. Provided the pedicle does not thrombose, skin flaps based on it may survive completely when elevated as early as 2 weeks after implantation. Flap survival depends on the development of a small number of vascular connections between vessels arising from the pedicle and preexisting dermal vessels. If elevation is delayed until 4 weeks after implantation a flap may survive even if its pedicle has thrombosed. Prolonged release of basic fibroblast growth factor adjacent to the pedicle significantly increases the survival of flaps elevated 1 week after implantation but does not alter the survival of flaps elevated at 2 and 4 weeks.
M J Hickey; Y Wilson; J V Hurley; W A Morrison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  101     ISSN:  0032-1052     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1296-304; discussion 1305-6     Citation Subset:  AIM; IM    
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MeSH Terms
Coloring Agents / diagnostic use
Dermatologic Surgical Procedures
Femoral Artery / physiology
Femoral Vein / physiology
Fibroblast Growth Factor 2 / administration & dosage,  therapeutic use*
Graft Survival
Muscle, Skeletal / blood supply,  physiology,  transplantation*
Neovascularization, Physiologic / drug effects,  physiology*
Regional Blood Flow / physiology
Skin / blood supply
Skin Transplantation / pathology*,  physiology
Surgical Flaps / blood supply*,  physiology
Thrombosis / etiology,  physiopathology
Time Factors
Vascular Patency
Reg. No./Substance:
0/Coloring Agents; 0/chinese ink; 103107-01-3/Fibroblast Growth Factor 2; 7440-44-0/Carbon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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