Document Detail

Mode of delivery, plasma catecholamines and Doppler-derived cardiac output in healthy term newborn infants.
MedLine Citation:
PMID:  1391254     Owner:  NLM     Status:  MEDLINE    
Umbilical cord arterial and venous concentrations of epinephrine, norepinephrine and the catecholamine metabolites 3,4-dihydroxyphenylglycol and 3,4-dihydroxyphenylacetic acid were determined in 41 healthy newborn infants delivered vaginally, vaginally with epidural analgesia, by cesarean section under general anesthesia or by cesarean section under epidural anesthesia. Doppler-derived cardiac output and arterial blood pressure were repeatedly measured during the first 48 h of life. There were fairly small differences in umbilical arterial and venous plasma concentrations of epinephrine and norepinephrine between the groups, with the highest levels of norepinephrine in infants delivered vaginally without analgesia (about 10 times as high as in the cesarean, general anesthetized group). No significant differences were found in the metabolite concentrations. Doppler-derived cardiac output and heart rate decreased in all groups during the study period and, in spite of increased catecholamine levels in the vaginally delivered infants, the differences between the groups were marginal. Healthy term infants with no signs of asphyxia were well prepared for a normal hemodynamic adaptation irrespective of mode of delivery or mode of obstetric anesthesia/analgesia.
H Hirsimäki; P Kero; H Ekblad; M Scheinin; M Saraste; R Erkkola
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  61     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-30     Completed Date:  1992-10-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  285-93     Citation Subset:  IM    
Department of Pediatrics, University of Turku, Finland.
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MeSH Terms
Analgesia, Epidural
Anesthesia, Epidural
Anesthesia, General
Blood Pressure / physiology
Cardiac Output / physiology*
Catecholamines / blood*
Delivery, Obstetric / methods*
Epinephrine / blood
Heart Rate / physiology
Hemodynamics / physiology
Infant, Newborn / blood*,  physiology*
Lactates / blood
Methoxyhydroxyphenylglycol / analogs & derivatives,  blood
Norepinephrine / blood
Reg. No./Substance:
0/Catecholamines; 0/Lactates; 23028-17-3/3,4-dihydroxyphenyllactic acid; 3343-19-9/dihydroxyphenylethylene glycol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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