Document Detail

Mode of death in adults with congenital heart disease.
MedLine Citation:
PMID:  11074209     Owner:  NLM     Status:  MEDLINE    
An increasing number of patients with congenital heart disease (CHD) are entering adulthood. Although prior studies have focused on the causes of death in the pediatric population, the modes of death for adults with CHD have not been well defined. In a cross-sectional study performed on a population of 2,609 consecutive adults assessed at a CHD specialty clinic, there were adequate information available in 197 of 199 deceased patients. Mean age at death was 37 +/- 15 years. Mortality was highest in patients with congenitally corrected transposition of the great arteries (26%), tricuspid atresia (25%), and univentricular connection (23%). Youngest mean age at death was observed in patients with tricuspid atresia (27 +/- 5 years), complete transposition of the great arteries (27 +/- 7 years), pulmonary atresia (27 +/- 6 years), and aortic coarctation (29 +/- 6 years). Sudden death (26%) was the most common cause of death followed by progressive heart failure (21%) and perioperative death (18%). Postmortem examinations were performed in 77 of 197 deceased patients (39%) and provided incremental data on the mechanism of death in 22% of autopsies. Thus, the 3 major causes of death in the growing population of adults with CHD are sudden, perioperative, and progressive heart failure.
E N Oechslin; D A Harrison; M S Connelly; G D Webb; S C Siu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-06     Completed Date:  2000-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1111-6     Citation Subset:  AIM; IM    
University of Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Age Distribution
Aged, 80 and over
Cause of Death*
Cross-Sectional Studies
Death, Sudden, Cardiac / etiology
Disease Progression
Heart Defects, Congenital / classification,  complications*,  mortality*,  surgery
Heart Failure / etiology,  mortality
Middle Aged
Ontario / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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