Document Detail

Mode of action studies on the formation of enamel minerals from a novel toothpaste containing calcium silicate and sodium phosphate salts.
MedLine Citation:
PMID:  24993853     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To investigate in vitro and in situ the deposition and formation of hydroxyapatite (HAP) on enamel surfaces following brushing with a novel toothpaste containing calcium silicate (CaSi), sodium phosphate salts and fluoride.
METHODS: Polished enamel blocks were brushed in vitro with a slurry of the CaSi toothpaste. After one brush and four weeks simulated brushing the enamel surfaces were analysed. In an in situ protocol, enamel blocks were attached to first or second molar teeth of healthy subjects, exposed to 4 weeks twice per day brushing with the CaSi toothpaste and then analysed. The surface deposits were analysed using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and selected area electron diffraction (SAED). In addition, the CaSi toothpaste was slurried in simulated oral fluid (SOF) over a 3 hour period and the solids were isolated and analysed by Fourier transform infrared spectroscopy (FTIR).
RESULTS: The FTIR study demonstrated that calcium phosphate phases had formed and these became increasingly crystalline over 3 hours. CaSi was deposited onto enamel surfaces following one brushing with the toothpaste in vitro.The deposited particles showed evidence of HAP crystalline phases associated with the CaSi. Following 4 weeks brushing in vitro, the deposition increased and analyses showed that the deposited material was HAP. These results were confirmed by the in situ study.
CONCLUSIONS: Calcium silicate can be deposited onto enamel surfaces from a novel toothpaste formulation where it can form the enamel mineral HAP.
CLINICAL SIGNIFICANCE: A novel toothpaste formulation containing CaSi can form HAP on enamel surfaces. The potential of this technology is for a novel approach to the repair of demineralised enamel and the protection of enamel during acid exposure.
Yuekui Sun; Xiaoke Li; Yan Deng; Jianing N Sun; DanYing Tao; Hui Chen; Qinghong Hu; Renjiang Liu; Weining Liu; Xiping Feng; Jinfang Wang; Mel Carvell; Andrew Joiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dentistry     Volume:  42 Suppl 1     ISSN:  1879-176X     ISO Abbreviation:  J Dent     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354422     Medline TA:  J Dent     Country:  England    
Other Details:
Languages:  eng     Pagination:  S30-8     Citation Subset:  D; IM    
Copyright Information:
© 2014 Elsevier Ltd. All rights reserved.
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