Document Detail


Mode of action of pesticides on aflatoxin biosynthesis and oxidase system activity.
MedLine Citation:
PMID:  10356798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of nine pesticides on the biosynthesis of aflatoxin and oxidase activity in wild-type Aspergillus flavus and mutant strains of A. parasiticus avr-1 (w 49) and A. parasiticus ver-1 (wh 1) were investigated. In A. parasiticus, phosphonic acid derivative (lancer) reduced the formation of aflatoxin B2 but B1, G1 and G2 and anthraquinones (versicolorin A, versiconal hemiacetal acetat and averufin) accumulated. Phosphorothioic acid derivatives (pirimiphos-methyl and pyrazophos) reduced the formation of aflatoxin B2 and G2 but B1 and G1 and anthraquinones accumulated. Phosphorodithioic acid derivatives (dimethoate and malathion) blocked aflatoxin B2, reduced B1 and G2 but G1 and anthraquinones accumulated. Phosphoric acid derivative (profenfos) inhibited the formation of all aflatoxins, versicolorin A and versiconal hemiacetal acetate but averufin accumulated. The phenylurea derivatives (linuron and pencycuron) at concentrations of 500 and 1000 ppm inhibited all aflatoxin but anthraquinones accumulated. On the other hand, the dicarboximide derivative (iprodione) inhibited the whole pathway in the mutant strains of A. parasiticus. The oxidase system in wild-type A. flavus was active in the conversion of averufin and versicolorin A into aflatoxin B1. Most organophosphate and phenylurea derivatives may competitively increase or decrease the oxidase enzymes, however, profenfos and iprodione blocked the enzymes between averufin and versicolorin A.
Authors:
H A Hasan
Related Documents :
6276838 - Search for effect of longitudinally polarized protons on optically active amino acid.
1632818 - Microsomal lauric acid hydroxylase activities after treatment of rats with three classi...
1646018 - Cytochromes c of nitrobacter winogradskyi and thiobacillus novellus: structure, functio...
1665758 - Bimane fluorogenic substrates for microdetermination of angiotensin converting enzyme l...
6276838 - Search for effect of longitudinally polarized protons on optically active amino acid.
19836938 - Maternal arachidonic acid supplementation improves neurodevelopment of offspring from h...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Microbiological research     Volume:  154     ISSN:  0944-5013     ISO Abbreviation:  Microbiol. Res.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-01     Completed Date:  1999-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437794     Medline TA:  Microbiol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Affiliation:
Botany Department, Faculty of Science, Assiut University, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aflatoxins / antagonists & inhibitors,  biosynthesis*
Anthraquinones / metabolism
Aspergillus / drug effects*,  metabolism
Biotransformation
Insecticides / pharmacology
Organothiophosphorus Compounds
Oxidoreductases / drug effects,  metabolism
Pesticides / pharmacology*
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Aflatoxins; 0/Anthraquinones; 0/Insecticides; 0/Organothiophosphorus Compounds; 0/Pesticides; EC 1.-/Oxidoreductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mineralization of benzo[a]pyrene by Marasmiellus troyanus, a mushroom isolated from a toxic waste si...
Next Document:  cDNA cloning of a sorghum pathogenesis-related protein (PR-10) and differential expression of defens...