Document Detail


Mode of action of oxanosine, a novel nucleoside antibiotic.
MedLine Citation:
PMID:  6288649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxanosine, a novel nucleoside, inhibits the growth of Escherichia coli K-12 on peptone agar, but not on Nutrient agar. This antibiotic activity was found to be bacteriostatic and was antagonized by guanine, guanosine, and guanylic acid. The growth of leukemia L 1210 cell was also inhibited by oxanosine, and the inhibition was reversed by guanylic acid. Oxanosine was confirmed to be a competitive inhibitor of GMP synthetase (E.C. 6.3.5.2) and the Ki value was 7.4 X 10(-4) M.
Authors:
N Yagisawa; N Shimada; T Takita; M Ishizuka; T Takeuchi; H Umezawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  35     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  755-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
5'-Guanylic Acid / pharmacology
Animals
Anti-Bacterial Agents / pharmacology*
Carbon-Nitrogen Ligases*
Escherichia coli / drug effects
Guanosine / pharmacology
Leukemia L1210 / drug therapy
Ligases / antagonists & inhibitors
Ribonucleosides / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Ribonucleosides; 118-00-3/Guanosine; 80394-72-5/oxanosine; 85-32-5/5'-Guanylic Acid; EC 6.-/Ligases; EC 6.3.-/Carbon-Nitrogen Ligases; EC 6.3.4.1/GMP synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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