| Modafinil in endozepine stupor. A case report. | |
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MedLine Citation:
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PMID: 15376490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit. METHOD: We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor. RESULTS: The vigilance promoting drug modafinil prevented recurrent episodes of stupor and coma in this patient at a dose of 200 mg/day for a period of six months. Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year. |
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Authors:
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Sharon Scott; Iftekhar Ahmed |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 31 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-20 Completed Date: 2004-10-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 409-11 Citation Subset: IM |
Affiliation:
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Department of Family Practice, Trinity Lutheran Hospital, Kansas City, Missouri, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Benzhydryl Compounds / administration & dosage* Central Nervous System Stimulants / administration & dosage* Coma / drug therapy*, etiology, prevention & control* Diazepam Binding Inhibitor / metabolism* Female Humans |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Central Nervous System Stimulants; 0/Diazepam Binding Inhibitor; 68693-11-8/modafinil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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