Document Detail


Modafinil decreases food intake in humans subjected to simulated shift work.
MedLine Citation:
PMID:  18573275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a limited number of studies modafinil has been shown to decrease food intake by laboratory animals and humans. The present study represents a secondary data analysis, in which the effects of modafinil on several measures of food intake were determined in humans living in a residential laboratory during simulated shift work. During this 23-day study, a wide selection of food items and beverages were freely available. During this double-blind, within-participant study, volunteers (N = 11) received oral modafinil dose (0, 200, or 400 mg) 1 h after waking for three consecutive days under two shift conditions: day shift and night shift. Shifts alternated three times during the study, and shift conditions were separated by an "off" day. Modafinil (200, 400 mg) dose-dependently decreased total caloric intake by approximately 18% and approximately 38%, respectively, regardless of shift condition, without selectively altering the proportion of total calories derived from carbohydrate, fat and protein. Ratings of "Hungry" were also significantly decreased by both active doses, but only immediately before the lunch break period. In addition, tolerance to the anorexic effects of modafinil was not apparent, as these effects remained stable across the three days of modafinil dosing. These findings show that modafinil produced clear reductions in food intake and suggest that future prospective studies should examine the drug in obese participants.
Authors:
Gydmer A Perez; Margaret Haney; Richard W Foltin; Carl L Hart
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  90     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2008-11-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-22     Citation Subset:  IM    
Affiliation:
Division on Substance Abuse, New York State Psychiatric Institute, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Benzhydryl Compounds / pharmacology*
Central Nervous System Stimulants / pharmacology*
Circadian Rhythm / physiology*
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Eating / drug effects*,  psychology
Energy Intake / drug effects
Female
Humans
Hunger / drug effects*
Male
Research Design
Grant Support
ID/Acronym/Agency:
DA-03746/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Central Nervous System Stimulants; 68693-11-8/modafinil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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