| Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. | |
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MedLine Citation:
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PMID: 8853524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anti-tumor effect and toxicity of chemotherapeutic agents are dose-related. The dose-response curve for these agents is sigmoidal with a threshold, a lag phase, a linear phase and a plateau phase. The aim of cancer chemotherapy is to exploit the difference between the response curves for the tumor and normal tissues. In the laboratory and in some animal models, the dose-response curve for many agents demonstrates a log-linear relationship between dose and cell kill so that a doubling of the drug dose may increase cell kill by ten-fold. The more effective a drug is, the steeper the dose-response curve. Dose may be an important variable in the outcome of therapy, however, this dose-response relationship has been difficult to demonstrate because a dose-response effect may not be evident for most human tumors in the dose ranges used in clinical trials. |
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Authors:
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N J Chao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of oncology Volume: 5 Suppl 1 ISSN: 1183-2509 ISO Abbreviation: Can J Oncol Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-12-24 Completed Date: 1996-12-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9305916 Medline TA: Can J Oncol Country: CANADA |
Other Details:
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Languages: eng Pagination: 43-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Stanford University Medical Center, CA 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage, adverse effects, therapeutic use* Cell Death Clinical Trials as Topic Disease Models, Animal Dose-Response Relationship, Drug Hematopoietic Cell Growth Factors / administration & dosage, therapeutic use* Hematopoietic Stem Cells / drug effects* Humans Linear Models Neoplasms / drug therapy Treatment Outcome Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Hematopoietic Cell Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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