Document Detail

Mobilization of peripheral blood progenitor cells by hematopoietic growth factors.
MedLine Citation:
PMID:  8853524     Owner:  NLM     Status:  MEDLINE    
The anti-tumor effect and toxicity of chemotherapeutic agents are dose-related. The dose-response curve for these agents is sigmoidal with a threshold, a lag phase, a linear phase and a plateau phase. The aim of cancer chemotherapy is to exploit the difference between the response curves for the tumor and normal tissues. In the laboratory and in some animal models, the dose-response curve for many agents demonstrates a log-linear relationship between dose and cell kill so that a doubling of the drug dose may increase cell kill by ten-fold. The more effective a drug is, the steeper the dose-response curve. Dose may be an important variable in the outcome of therapy, however, this dose-response relationship has been difficult to demonstrate because a dose-response effect may not be evident for most human tumors in the dose ranges used in clinical trials.
N J Chao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of oncology     Volume:  5 Suppl 1     ISSN:  1183-2509     ISO Abbreviation:  Can J Oncol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9305916     Medline TA:  Can J Oncol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  43-6     Citation Subset:  IM    
Department of Medicine, Stanford University Medical Center, CA 94305, USA.
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MeSH Terms
Antineoplastic Agents / administration & dosage,  adverse effects,  therapeutic use*
Cell Death
Clinical Trials as Topic
Disease Models, Animal
Dose-Response Relationship, Drug
Hematopoietic Cell Growth Factors / administration & dosage,  therapeutic use*
Hematopoietic Stem Cells / drug effects*
Linear Models
Neoplasms / drug therapy
Treatment Outcome
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Hematopoietic Cell Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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