Document Detail

Mobilization of arachidonic acid from diacyl and ether-linked phospholipids in FMLP stimulated alveolar macrophages.
MedLine Citation:
PMID:  3276328     Owner:  NLM     Status:  MEDLINE    
Exposure of [1 14C]AA labeled guinea-pig alveolar macrophages to FMLP for 15 min induced an extensive mobilization of AA from phospholipids. PC and PI mainly contributed to the AA release, and labeled PE remained unchanged. Analysis of ether-linked phospholipids showed a significant breakdown of labeled diacyl and alkyl-acyl PC and an increase in labeled alkenyl-acyl PE.
J Masliah; M Bachelet; O Colard; G Bereziat; B B Vargaftig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  37     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-02-25     Completed Date:  1988-02-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  547-50     Citation Subset:  IM    
Laboratoire de Biochimie, C.H.U.-Saint-Antoine, Paris, France.
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MeSH Terms
Arachidonic Acids / metabolism*
Carbon Radioisotopes
Guinea Pigs
Macrophages / drug effects,  metabolism*
N-Formylmethionine Leucyl-Phenylalanine / pharmacology*
Phospholipids / metabolism*
Radioisotope Dilution Technique
Reg. No./Substance:
0/Arachidonic Acids; 0/Carbon Radioisotopes; 0/Phospholipids; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine

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