Document Detail


Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent.
MedLine Citation:
PMID:  16878295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have examined in vitro cell response to mobile phone radiation (900 MHz GSM signal) using two variants of human endothelial cell line: EA.hy926 and EA.hy926v1. Gene expression changes were examined in three experiments using cDNA Expression Arrays and protein expression changes were examined in ten experiments using 2-DE and PDQuest software. Obtained results show that gene and protein expression were altered, in both examined cell lines, in response to one hour mobile phone radiation exposure at an average specific absorption rate of 2.8 W/kg. However, the same genes and proteins were differently affected by the exposure in each of the cell lines. This suggests that the cell response to mobile phone radiation might be genome- and proteome-dependent. Therefore, it is likely that different types of cells and from different species might respond differently to mobile phone radiation or might have different sensitivity to this weak stimulus. Our findings might also explain, at least in part, the origin of discrepancies in replication studies between different laboratories.
Authors:
Reetta Nylund; Dariusz Leszczynski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proteomics     Volume:  6     ISSN:  1615-9853     ISO Abbreviation:  Proteomics     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  4769-80     Citation Subset:  IM    
Affiliation:
Functional Proteomics Group, Radiation Biology Laboratory, STUK, Radiation and Nuclear Safety Authority, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Cell Proliferation
Cellular Phone*
Electrophoresis, Gel, Two-Dimensional
Endothelial Cells / cytology,  metabolism*,  radiation effects*
Gene Expression Regulation / genetics,  radiation effects*
Genome, Human / genetics*
Humans
Proteome / genetics*,  metabolism*
Chemical
Reg. No./Substance:
0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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