Document Detail

MnDPDP-enhanced MR imaging of the liver. Correlation with surgical findings.
MedLine Citation:
PMID:  9245959     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare lesion detection and characterisation predicted by MnDPDP-enhanced MR imaging with surgical excision and pathological examination. MATERIAL AND METHODS: Ninety patients were intravenously infused at a rate of 2 to 3 ml/min with 5 mumol/kg mangafodipir trisodium (MnDPDP, Teslascan). The patients were examined with spin-echo and gradient-echo T1-weighted MR imaging at 1 h and 24 h after the end of infusion. The results were compared with identical pre-contrast sequences. In 20 of these patients, the pre-operative MR findings were compared with intra-operative ultrasonography and histology of the resected liver specimens. RESULTS: In those with liver metastases, there was a good correlation between MR and the hepatic disease in 11 out of 14 cases. In the group with primary liver tumours, MR findings correlated with hepatic disease in 5 out of 6 cases. CONCLUSION: Liver lesion characterisation is possible with MnDPDP, and MR contrast enhancement with this agent is considered to be an important adjunct to the radiological assessment of patients with neoplastic liver disease where accurate decisions for surgical planning are imperative.
P A Kane; V Ayton; H L Walters; I Benjamin; N D Heaton; R Williams; J B Karani
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  38     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-28     Completed Date:  1997-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Department of Radiology, Kings College Hospital, London, UK.
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MeSH Terms
Contrast Media* / administration & dosage
Edetic Acid / administration & dosage,  analogs & derivatives*,  diagnostic use
Guinea Pigs
Liver / pathology*,  surgery*
Liver Neoplasms / diagnosis,  secondary,  surgery
Magnetic Resonance Imaging / methods*
Manganese / administration & dosage,  diagnostic use*
Middle Aged
Pyridoxal Phosphate / administration & dosage,  analogs & derivatives*,  diagnostic use
Reg. No./Substance:
0/Contrast Media; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 7439-96-5/Manganese
Comment In:
Acta Radiol. 1997 Jul;38(4 Pt 2):623-5   [PMID:  9245954 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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