| Mn-Porphyrins as Novel Molecular MRI Contrast Agents. | |
| | |
MedLine Citation:
|
PMID: 22050509 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: In these experiments, we investigated a new class of therapeutic metalloporphyrins and their potential as molecular MR imaging probes for prostate cancer (PCa). Mn(III)TE-2-Pyp5+ (meso-tetrakis(N-ethyl-2-prydil)porphyrin) and Mn(III)TnHex-2-PYP5+ (meso-tetrakis(N-n-hexyl-2-pyridyl)porphyrin are powerful superoxide dismutase mimics with low toxicity and antineoplastic activity. Methods: MR imaging experiments were performed at 7.0T on a Bruker Biospec horizontal bore scanner. All in vivo experiments were performed on twelve C57 black mice implanted with RM-9 PCa cells on the hind-limb location. 10 mg/kg of MnTn-Hex-2-PyP (n=6) and 2 mg/kg MnTE-2-PyP (n=6) were administered intraperitoneally 60 and 120 minutes prior to imaging. All the images were collected using a volume coil and processed using Paravision 4.0. Results: Phantom studies reveal remarkably high T1 relaxivity changes for both hexyl and ethyl analogues, which are several-fold higher than commercially available gadolinium chelates. Observable detection limits were in the low micromolar range, 1-2 orders of magnitude lower than conventional chelates. In vivo, we readily observed MR relaxation changes in prostate tumor xenografts after a single injection of either ethyl and hexyl analogues, although T1 shortening was highest after hexyl administration. Conclusion: Following a single dose of Mn-Porphyrins, relaxation changes in prostate tumors measured 10-11 folds greater than in surrounding tissues, suggesting these probes may be particularly effective in imaging PCa foci in vivo. |
| | |
Authors:
|
Vladimir Mouraviev; Masaki Kimura; Talaignair Venkatraman; Matvey Tsivian; Vladimira Mouravieva; Ines Batinic-Haberle; Tom James Polascik; Haichen Wang; Chris Lascola |
Related Documents
:
|
21040869 - Automated extraction of radiation dose information for ct examinations. 22183839 - Recalibrating the gram stain diagnosis of male urethritis in the era of nucleic acid am... 8837279 - Radiation dose by spiral ct and conventional tomography of the sternoclavicular joints ... 12558079 - Ct- and mr colonography. 15088109 - Magnetic resonance imaging based colonography for diagnosis and assessment of diverticu... 12124239 - Primary radiation outside the imaged volume of a multislice helical ct scan. 1376669 - Rapid stream stimulation and the recognition potential. 10369359 - Mr spectroscopy of bilateral thalamic gliomas. 10908969 - Incidence and growth pattern of vestibular schwannomas in a danish county, 1977-98. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-3 |
Journal Detail:
|
Title: Journal of endourology / Endourological Society Volume: - ISSN: 1557-900X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807503 Medline TA: J Endourol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University of Cincinnati, Urology/Surgery, 231 Albert Sabin Way, ML 0589, Cinicnnati, Ohio, United States, 45267, 513-558-4388, 513-558-3575; mouravvr@ucmail.uc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: DOES THE PRESENCE OF MEDIAN LOBE AFFECT PERIOPERATIVE OUTCOMES, POSITIVE SURGICAL MARGIN RATES AND E...
Next Document: Preoperative Warming Up Exercises Improves Laparoscopic Operative Times in an Experienced Laparoscop...