Document Detail

Mizoribine-mediated apoptotic signaling pathway in human T-Cell line.
MedLine Citation:
PMID:  15808579     Owner:  NLM     Status:  MEDLINE    
Mizoribine (MZR), an inhibitor of inosine monophosphate dehydrogenase, which depletes cellular guanadine triphosphate, is an immunosuppressive drug. The aim of this study was to evaluate the mechanism by which MZR exerts cytotoxic effects on human Jurkat T cells. Our study showed that MZR-induced apoptotic death of human Jurkat T cells is dose-dependent and time-dependent, as revealed by chromatin condensation and H2AX phosphorylation. Furthermore, MZR increased the catalytic activity of caspase family cysteine proteases, including caspase-3, caspase-8, and caspase-9, in human Jurkat T cells. In conclusion, MZR induces the apoptotic death of human Jurkat T cells via activation of caspase family proteases as well as by mitochondrial dysfunction.
K W Seo; H K Lee; S J N Choi; B J So; S K Kim; S Y Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-10-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Division of Transplantation Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
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MeSH Terms
Apoptosis / drug effects*
Caspases / metabolism
Cell Line
Cell Nucleus / drug effects,  ultrastructure
Cell Survival / drug effects
Immunosuppressive Agents / pharmacology*
Jurkat Cells
Proto-Oncogene Proteins c-bcl-2 / drug effects,  metabolism
Ribonucleosides / pharmacology*
Signal Transduction / drug effects*
T-Lymphocytes / drug effects,  immunology
bcl-X Protein
Reg. No./Substance:
0/BCL2L1 protein, human; 0/Immunosuppressive Agents; 0/Proto-Oncogene Proteins c-bcl-2; 0/Ribonucleosides; 0/bcl-X Protein; 50924-49-7/bredinin; EC 3.4.22.-/Caspases

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