Document Detail

Mixture models for the joint distribution of repeated measures and event times.
MedLine Citation:
PMID:  9004395     Owner:  NLM     Status:  MEDLINE    
Many long-term clinical trials collect both a vector of repeated measurements and an event time on each subject; often, the two outcomes are dependent. One example is the use of surrogate markers to predict disease onset or survival. Another is longitudinal trials which have outcome-related dropout. We describe a mixture model for the joint distribution which accommodates incomplete repeated measures and right-censored event times, and provide methods for full maximum likelihood estimation. The methods are illustrated through analysis of data from a clinical trial for a new schizophrenia therapy; in the trial, dropout time is closely related to outcome, and the dropout process differs between treatments. The parameter estimates from the model are used to make a treatment comparison after adjusting for the effects of dropout. An added benefit of the analysis is that it permits using the repeated measures to increase efficiency of estimates of the event time distribution.
J W Hogan; N M Laird
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Statistics in medicine     Volume:  16     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:    1997 Jan 15-Feb 15
Date Detail:
Created Date:  1997-03-26     Completed Date:  1997-03-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  239-57     Citation Subset:  IM    
Center for Statistical Sciences, Brown University, Providence, RI 02912, USA.
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MeSH Terms
Clinical Trials as Topic / methods*
Confidence Intervals
Likelihood Functions
Linear Models
Longitudinal Studies
Models, Statistical*
Reproducibility of Results
Schizophrenia / drug therapy
Time Factors
Grant Support

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