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Mixture of ferric sodium ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate: an effective iron fortificant for complementary foods for young Chinese children.
MedLine Citation:
PMID:  22908692     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Ferric sodium ethylenediaminetetraacetate (NaFeEDTA) enhances iron absorption in the presence of phytate. However, the amount of NaFeEDTA that would have to be added to a complementary food to provide the necessary intake of iron for an infant or young child if NaFeEDTA were the sole iron fortificant exceeds the Acceptable Daily Intake (ADI) of EDTA for this age group. EDTA increases iron absorption at a molar ratio EDTA:iron of less than 1:1.
OBJECTIVE: To determine whether iron absorption is enhanced with a mixture offerrous sulfate (FeSO4) and NaFeEDTA.
METHODS: Two studies with a crossover design were conducted in separate groups of 14 and 15 children aged 24 to 31 months. A complementary food consisting of millet porridge with cabbage, tofu, and pork-filled wheat flour dumplings was fortified with 2 mg iron as either FeSO4 or NaFeEDTA (study 1) or 4 mg iron as FeSO4 or a mixture of 2 mg each of FeSO4 and NaFeEDTA (study 2). Iron absorption was determined based on erythrocyte incorporation of stable iron isotopes.
RESULTS: In study 1, the geometric mean (+ SD) iron absorption was 8.0% (3.1, 20.8) and 9.2% (3.1, 27.0) from food fortified with FeSO, and NaFeEDTA, respectively. In study 2, iron absorption was significantly higher from food fortified with 4 mg iron as 1:1 mixture of FeSO/NaFeEDTA than from food fortified with FeSO4; the geometric mean iron absorption was 6.4% (3.0, 13.5) and 4.1% (1.9, 8.9), respectively.
CONCLUSIONS: The enhancing effect of EDTA on iron absorption is less strong in composite meals containing enhancers; nevertheless, the equal mixture of FeSO4 and NaFeEDTA significantly enhanced iron absorption and can be a strategy to ensure adequate iron absorption from phytate-containing complementary foods.
Authors:
Suying Chang; Zhenwu Huang; Yuxia Ma; Jianhua Piao; Xiaoguang Yang; Christophe Zeder; Richard F Hurrell; Ines Egli
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and nutrition bulletin     Volume:  33     ISSN:  0379-5721     ISO Abbreviation:  Food Nutr Bull     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-08-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906418     Medline TA:  Food Nutr Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Affiliation:
Key Laboratory of Trace Element Nutrition of the Ministry of Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China.
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