Document Detail

Mixing studies during intracarotid artery infusions in an in vitro model.
MedLine Citation:
PMID:  3944637     Owner:  NLM     Status:  MEDLINE    
Sporadic instances of retinal damage and of focal brain toxicity have been observed following intracarotid artery infusions of chemotherapeutic agents (such as BCNU and cis-platinum) for the treatment of glioblastomas. The episodic nature of these toxicities is consistent with the possibility that the drug solutions were streaming from the catheter tip and, therefore, were not well mixed or not uniformly distributed in all branches distal to the catheter tip location. To test this hypothesis, an in vitro system was fabricated which included a transparent model of the human carotid artery and its major branches. These were furnished with pulsatile flow of a blood simulant. Dye solutions infused at several infusion rates through various types of catheters in both supraophthalmic and infraophthalmic positions were monitored and recorded on videotape and photographic film. The effluent streams from distal branches of the model were collected, and the relative concentrations of dye in each branch were determined spectrophotometrically. The results indicate that infusate streaming occurs at low infusion rates. In some cases, the concentration in a given branch can be at least five times the expected concentration. Similar occurrences of streaming in vivo could cause focal toxicity. Methods to improve mixing should be used during intra-arterial administration of drugs; these include increasing the infusion rates and improving catheter tip design.
R J Lutz; R L Dedrick; J W Boretos; E H Oldfield; J B Blacklock; J L Doppman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  64     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-02-28     Completed Date:  1986-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  AIM; IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage
Carotid Arteries*
Infusions, Intra-Arterial / methods*
Reg. No./Substance:
0/Antineoplastic Agents

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