| Mixed results with modulation of TH-17 cells in human autoimmune diseases. | |
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MedLine Citation:
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PMID: 20016509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The outcomes of clinical trials provide the most convincing data to clarify the role of particular cytokines in the pathogenesis of human diseases. The immunology community, for a variety of practical reasons, spends most of its research time and funds on studies in model systems, mainly mice. In this perspective I discuss results of clinical trials assessing the effect of blocking the differentiation and/or function of interleukin-17-producing CD4(+) T cells on human autoimmune disease, and devote more limited attention to corroborating preclinical studies from animal models. Thus far, these outcomes in human trials have been mixed, with notable success in psoriasis and Crohn's disease but a negative result in relapsing-remitting multiple sclerosis. |
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Authors:
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Lawrence Steinman |
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Publication Detail:
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Type: Journal Article Date: 2009-12-17 |
Journal Detail:
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Title: Nature immunology Volume: 11 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-01-14 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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Department of Neurological Sciences and Interdepartmental Program in Immunology, Beckman Center for Molecular Medicine, Stanford University School of Medicine, Stanford, California, USA. steinman@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / pharmacology Autoimmune Diseases / immunology*, metabolism Cell Differentiation / immunology* Humans Interleukin-12 Subunit p40 / immunology, metabolism Interleukin-17 / immunology*, metabolism Models, Biological Multiple Sclerosis, Relapsing-Remitting / drug therapy, immunology, metabolism T-Lymphocytes, Helper-Inducer / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS055997-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Interleukin-12 Subunit p40; 0/Interleukin-17; 0/ustekinumab |
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