Document Detail

Mixed phenotype of blasts in acute megakaryocytic leukaemia and transient abnormal myelopoiesis in Down's syndrome.
MedLine Citation:
PMID:  1390239     Owner:  NLM     Status:  MEDLINE    
Blasts from eight cases with acute megakaryoblastic leukaemia (AMKL) and seven with transient abnormal myelopoiesis in Down's syndrome (TAM) were investigated to clarify their phenotypic characteristics. CD41 and CD7 were the most frequently expressed in both disorders. CD41 was positive in six TAM and five AMKL cases, and CD7 was positive in five TAM and five AMKL cases, respectively. CD33 was detected in four TAM and five AMKL cases. Other myeloid-lineage associated antigens such as CD13 and CD11b could not be found in TAM but were expressed in five AMKL cases. Interestingly, CD56, a neural adhesion molecule, was expressed in three of four TAM and one of five AMKL cases. Cytoplasmic CD3 antigen was also noted in three of five examined cases. A short-term culture study was conducted on blasts from two TAM cases and five AMKL cases. In two cases in which CD41 was not expressed before culture, the expression of CD41 was enhanced after culture with or without 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The expression of CD7 remarkably was depressed, while that of CD13 was enhanced after culture with TPA. These findings suggest that blasts of TAM and AMKL originate from very immature cells and represent a mixed phenotype. In the present study, distinction of phenotypical differences between blast in TAM and AMKL was not possible.
K Yumura-Yagi; J Hara; H Kurahashi; T Nishiura; Y Kaneyama; Y Osugi; N Sakata; M Inoue; A Tawa; S Okada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  81     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  520-5     Citation Subset:  IM    
Department of Paediatrics, Osaka University Hospital, Japan.
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MeSH Terms
Antigens, CD / analysis
Antigens, CD3 / analysis
Bone Marrow / immunology*
Child, Preschool
Down Syndrome / immunology*
HLA-DR Antigens / analysis
Infant, Newborn
Leukemia, Megakaryoblastic, Acute / immunology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD3; 0/HLA-DR Antigens

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