Document Detail

Mixed papillary transitional cell carcinoma and adenocarcinoma of the uterine cervix: a clinicopathologic study of three cases.
MedLine Citation:
PMID:  12819386     Owner:  NLM     Status:  MEDLINE    
Although tumors consisting of a combination of transitional cell carcinoma (TCC) and adenocarcinoma have been described in the endometrium, they have not been documented in the uterine cervix to our knowledge. Three such cervical cases are reported in this article. Three patients, whose ages ranged from 40 to 61 years, presented with vaginal bleeding and malignant cells on routine Papanicolaou smears. The initial diagnoses based on a biopsy specimen were poorly differentiated squamous cell carcinoma in two patients and adenocarcinoma with a solid component in the third patient. All patients underwent radical hysterectomy. The hysterectomy specimens each contained a polypoid endocervical mass with minimal invasion of the cervical stroma. On microscopic examination, each tumor consisted of a component of papillary TCC admixed with an adenocarcinoma of endometrioid type. Both carcinomatous components were immunoreactive for cytokeratin (CK) 7 but not CK20. The three patients were alive and disease-free from 10 months to 4 years postoperatively. Recognition of this unusual variant of cervical carcinoma is important to delineate its clinical and pathologic features and establish prognostic differences, if any, from other histologic subtypes of cervical carcinoma. Papillary TCC mixed with adenocarcinoma broadens the morphologic spectrum of transitional cell neoplasms of the uterine cervix.
Claudius E Robinson; Venetia Rumnong Sarode; Jorge Albores-Saavedra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  22     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
Division of Anatomic Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
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MeSH Terms
Adenocarcinoma / pathology*,  surgery
Carcinoma, Transitional Cell / pathology*,  surgery
Intermediate Filament Proteins / analysis
Keratins / analysis
Middle Aged
Neoplasms, Multiple Primary / pathology*,  surgery
Uterine Cervical Neoplasms / pathology*,  surgery
Uterine Hemorrhage
Vaginal Smears
Reg. No./Substance:
0/Intermediate Filament Proteins; 0/KRT20 protein, human; 0/KRT7 protein, human; 0/Keratin-20; 0/Keratin-7; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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