Document Detail


Mixed oxo-hydroxy bile acids as actual or potential impurities in ursodeoxycholic acid preparation: a 1H and 13C NMR study.
MedLine Citation:
PMID:  10755232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some distinctive unprecedented 1H NMR signals and the complete 13C NMR resonances are assigned for the entire set of mixed oxo-hydroxy bile acid isomers, obtained by selective oxidation of the hydroxy groups at positions (3,7), (3,12) and (3,7,12) of chenodesoxycholic acid, desoxycholic acid and cholic acid, respectively. Partially or totally oxidized products are the major actual or potential impurities formed during the preparation of the pharmaceutically active ursodeoxycholic and chenodeoxycholic acids.
Authors:
L Bettarello; O Bortolini; G Fantin; A Guerrini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  55     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Affiliation:
Dipartimento di Chimica, Università di Ferrara, Italy.
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MeSH Terms
Descriptor/Qualifier:
Bile Acids and Salts / isolation & purification*
Carbon Isotopes
Magnetic Resonance Spectroscopy
Protons
Ursodeoxycholic Acid / chemistry*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Carbon Isotopes; 0/Protons; 128-13-2/Ursodeoxycholic Acid

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