| Mixed oxo-hydroxy bile acids as actual or potential impurities in ursodeoxycholic acid preparation: a 1H and 13C NMR study. | |
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MedLine Citation:
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PMID: 10755232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Some distinctive unprecedented 1H NMR signals and the complete 13C NMR resonances are assigned for the entire set of mixed oxo-hydroxy bile acid isomers, obtained by selective oxidation of the hydroxy groups at positions (3,7), (3,12) and (3,7,12) of chenodesoxycholic acid, desoxycholic acid and cholic acid, respectively. Partially or totally oxidized products are the major actual or potential impurities formed during the preparation of the pharmaceutically active ursodeoxycholic and chenodeoxycholic acids. |
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Authors:
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L Bettarello; O Bortolini; G Fantin; A Guerrini |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 55 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-06-08 Completed Date: 2000-06-08 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Dipartimento di Chimica, Università di Ferrara, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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isolation & purification* Carbon Isotopes Magnetic Resonance Spectroscopy Protons Ursodeoxycholic Acid / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Carbon Isotopes; 0/Protons; 128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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