Document Detail


Mixed lipid phase SMEDDS as an innovative approach to enhance resveratrol solubility.
MedLine Citation:
PMID:  23301796     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Context: Despite its promising therapeutic activities, clinical use of resveratrol (RSV) is compromised with unfavorable biopharmaceutical properties, namely low water solubility. Objective: This work deals with improving RSV solubility and release rate through its incorporation in innovative mixed lipid phase self-microemulsifying drug delivery systems (SMEDDS). Methods: (Pseudo)ternary diagrams were constructed for different oils and surfactant mixtures. Selected systems were further evaluated for RSV solubility, self-emulsification ability, accelerated stability, dynamic viscosity, compatibility with hard gelatin capsules and in vitro dissolution of RSV. Results: Lipid phase composed of diverse lipid species, castor oil (long-chained triglyceride) and Capmul MCM (mixture of medium chain mono and diglycerides) allowed formulation of mixed lipid SMEDDS with lower surfactants content (60% Cremophor EL/RH 40/RH 60). Mixed lipid phase SMEDDS showed best self-emulsifying ability with regard to self-emulsifying time as well as droplet size and monodispersity of microemulsions obtained upon SMEDDS dilution with aqueous phase. Overall, incorporation of RSV in SMEDDS resulted in improved solubility (over 23-fold) and dissolution rate compared to crystalline RSV. All SMEDDS formulations were adequately viscous for filling into hard gelatin capsules (>150 mPaċs for empty SMEDDS; >400 mPaċs for RSV-loaded SMEDDS) and no leaking was observed during three months of storage. Conclusion: The presented work indicates the promising potential of mixed lipid SMEDDS formulations for future development of SMEDDS with lower surfactant content and no added cosolvents for incorporation of RSV and other poorly soluble drugs.
Authors:
Katarina Bolko; Alenka Zvonar; Mirjana Gašperlin
Related Documents :
23966986 - Impact of seasonal hydrological variation on the distributions of tetraether lipids alo...
24713146 - Functional properties of ultrasonically generated flaxseed oil-dairy emulsions.
22975626 - Vegetable oil thermosets reinforced by tannin-lipid formulations.
9149296 - Interactions between angiotensin ii and delta opioid receptor subtype agonists upon wat...
21755996 - Measuring picogram per liter concentrations of freely-dissolved parent and alkyl pahs (...
17929806 - The thermodynamic solvate difference rule: solvation parameters and their use in interp...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  -     ISSN:  1520-5762     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Pharmacy, University of Ljubljana , Askerceva 7, Ljubljana , Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How do design features influence consumer attention when looking for nutritional information on food...
Next Document:  The hyperpolarization-activated non-specific cation current (I(h) ) adjusts the membrane properties,...