Document Detail


Mixed lignan-neolignans from Tarenna attenuata.
MedLine Citation:
PMID:  17343407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Six new mixed lignan-neolignans and 20 known compounds were isolated from the whole plant of Tarenna attenuata. By analysis of physical and spectroscopic data, the structures of the new compounds were elucidated as (1R,5R,6R)-6-{4-O-[2-(1-(4-hydroxy-3-methoxyphenyl))glycerol]-3,5-dimethoxyphenyl}-3,7-dioxabicyclo[3.3.0]octan-2-one (1), 5' '-methoxyhedyotisol A (2), 4' '-O-(8-guaiacylglycerol)buddlenol A (3), 5' '-methoxy-4' '-O-(8-guaiacylglycerol)buddlenol A (4), 4,6-dimethoxy-5-hydroxy-3-hydroxymethyl-2-(3,4,5-trimethoxyphenyl)-2,3-dihydrobenzofuran (5), and 7-O-ethylguaiacylglycerol (6). Compounds 1, 5, 6, and 8 showed potent antioxidant activities against H2O2-induced impairment in PC12 cells, and compounds 1, 2, 5, and 7 scavenged DPPH radical strongly with IC50 values of 72, 87, 45, and 55 microM, respectively.
Authors:
Xian-Wen Yang; Pei-Ji Zhao; Yan-Lin Ma; Hai-Tao Xiao; Yi-Qing Zuo; Hong-Ping He; Ling Li; Xiao-Jiang Hao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-08
Journal Detail:
Title:  Journal of natural products     Volume:  70     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-05-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-5     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / chemistry,  isolation & purification*,  pharmacology
Animals
Antioxidants / pharmacology
Biphenyl Compounds
Drugs, Chinese Herbal / chemistry,  isolation & purification*,  pharmacology
Free Radical Scavengers / pharmacology
Hydrogen Peroxide / pharmacology
Inhibitory Concentration 50
Lignans / chemistry,  isolation & purification*,  pharmacology
PC12 Cells
Picrates / pharmacology
Plants, Medicinal / chemistry*
Rats
Rubiaceae / chemistry*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Antioxidants; 0/Biphenyl Compounds; 0/Drugs, Chinese Herbal; 0/Free Radical Scavengers; 0/Lignans; 0/Picrates; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 7722-84-1/Hydrogen Peroxide

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