Document Detail

Mixed germ cell malignancy of the ovary concurrent with pregnancy.
MedLine Citation:
PMID:  9205440     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A rare malignant germ cell tumor of the ovary during pregnancy was detected by screening of maternal serum alpha-fetoprotein (MSAFP). Treatment of this uncommon tumor during pregnancy incorporated combination chemotherapy including etoposide. CASE: An 18-year-old primiparous woman undergoing antenatal genetic screening was found to have an extremely elevated MSAFP of 477.8 IU/mL, or 12.46 multiples of the median. Oophorectomy and staging laparotomy at 20.5 weeks' gestation resulted in the diagnosis of mixed germ cell tumor of the ovary, with both endodermal sinus tumor and grade 3 immature teratoma. The patient received three courses of cis-platinum, etoposide, and bleomycin. Maternal serum AFP titers had returned to normal pregnancy levels by the start of the second course. A healthy female infant was delivered at 39 weeks' gestation following induction of labor for pregnancy-induced hypertension. CONCLUSION: Elevated MSAFP levels may be a presenting sign of malignant ovarian germ cell neoplasms. This report describes both surgical and chemotherapeutic treatment of a germ cell malignancy during pregnancy, with delivery at term. To date, major fetal toxicity from chemotherapy has not been identified.
D Horbelt; J Delmore; R Meisel; S Cho; D Roberts; D Logan
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Pediatrics, and Family Medicine, University of Kansas School of Medicine-Wichita, USA.
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MeSH Terms
Germinoma* / blood,  diagnosis,  drug therapy
Ovarian Neoplasms* / blood,  diagnosis,  drug therapy
Pregnancy Complications, Neoplastic* / blood,  diagnosis,  drug therapy
alpha-Fetoproteins / analysis
Reg. No./Substance:

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