Document Detail


Mixed fermentation for natural product drug discovery.
MedLine Citation:
PMID:  19305992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural products continue to play a major role in drug discovery and development. However, chemical redundancy is an ongoing problem. Genomic studies indicate that certain groups of bacteria and fungi have dozens of secondary metabolite pathways that are not expressed under standard laboratory growth conditions. One approach to more fully access the metabolic potential of cultivatable microbes is mixed fermentation, where the presence of neighboring microbes may induce secondary metabolite synthesis. Research to date indicates that mixed fermentation can result in increased antibiotic activity in crude extracts, increased yields of previously described metabolites, increased yields of previously undetected metabolites, analogues of known metabolites resulting from combined pathways and, importantly, induction of previously unexpressed pathways for bioactive constituents.
Authors:
Robin K Pettit
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-21
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  83     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-21     Completed Date:  2009-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-2404, USA. robin.pettit@asu.edu
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MeSH Terms
Descriptor/Qualifier:
Bacteria / growth & development,  metabolism*
Biological Products / isolation & purification*,  pharmacology*
Drug Discovery / methods*
Fermentation
Fungi / growth & development,  metabolism*
Grant Support
ID/Acronym/Agency:
2R56 CA090441-06A1/CA/NCI NIH HHS; 5R01 CA090441-07/CA/NCI NIH HHS; R01 CA90441-01-05/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Products

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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