| Mivacurium infusion requirements in pediatric surgical patients during nitrous oxide-halothane and during nitrous oxide-narcotic anesthesia. | |
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MedLine Citation:
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PMID: 2141969 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We were interested in determining the infusion rate of mivacurium required to maintain approximately 95% neuromuscular blockade during nitrous oxide-halothane (0.8% end-tidal) or nitrous oxide-narcotic anesthesia. Neuromuscular blockade was monitored by recording the electromyographic activity (Datex NMT) of the adductor pollicis muscle resulting from supramaximal stimulation of the ulnar nerve at 2 Hz for 2 s at 10-s intervals. Mivacurium steady-state infusion requirements averaged 315 +/- 26 micrograms.m-2.min-1 during nitrous oxide-halothane anesthesia and 375 +/- 19 micrograms.m-2.min-1 (mean +/- SEM) during nitrous oxide-narcotic anesthesia. Higher levels of pseudocholinesterase activity were generally associated with a higher mivacurium infusion requirement. During both anesthetics, younger age was associated with a higher infusion requirement when the infusion requirement was calculated in terms of micrograms.kg-1.min-1. This difference was not present when the infusion rate was calculated in terms of micrograms.m-2.m-1. There was no evidence of cumulation during prolonged mivacurium infusion. There was no difference in the rates of spontaneous or reversal-mediated recovery between anesthetic groups. After the termination of the infusion, spontaneous recovery to T4/T1 greater than or equal to 0.75 occurred in 9.8 +/- 0.4 min, with a recovery index, T25-75, of 4.0 +/- 0.2 min (mean +/- SEM). In summary, pseudocholinesterase activity is the major factor influencing mivacurium infusion rate in children during nitrous oxide-narcotic or nitrous oxide-halothane (0.8% end-tidal) anesthesia. |
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Authors:
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B W Brandom; J B Sarner; S K Woelfel; M L Dong; M C Horn; L M Borland; D R Cook; V J Foster; B F McNulty; J N Weakly |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 71 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-06 Completed Date: 1990-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 16-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Children's Hospital of Pittsburgh, PA 15213-2583. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Inhalation* Child Child, Preschool Diazepam Halothane* Humans Infusions, Intravenous Isoquinolines* Methohexital Morphine Neuromuscular Junction / drug effects* Neuromuscular Nondepolarizing Agents / administration & dosage*, therapeutic use Nitrous Oxide* Pediatrics Pseudocholinesterase / metabolism Scopolamine |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 10024-97-2/Nitrous Oxide; 106791-40-6/mivacurium; 151-67-7/Halothane; 18652-93-2/Methohexital; 439-14-5/Diazepam; 51-34-3/Scopolamine; 57-27-2/Morphine; EC 3.1.1.-/Pseudocholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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