Document Detail

Mitral web--a new concept for mitral valve repair: improved engineering design and in-vitro studies.
MedLine Citation:
PMID:  19557987     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: A new mitral valve repair concept to treat mitral regurgitation (MR) due to valve prolapse was recently proposed. In this study, an improved design of this concept is presented, and the results of preliminary hemodynamic studies conducted in an in-vitro prolapse model are reported. METHODS: The new repair approach is based on using a web/net attached to a standard annuloplasty ring spanning the annulus of the mitral valve. Experiments were conducted in a left ventricular simulator, using native porcine mitral valves. Severe MR was created by transecting the marginal chordae to induce P2 prolapse, and also by displacing the papillary muscles basally to induce bileaflet prolapse. RESULTS: Implantation of the mitral web prevented leaflet prolapse and restored leaflet coaptation with trace mitral insufficiency, in both posterior and bileaflet prolapse. In posterior leaflet prolapse, implantation of the mitral web reduced the regurgitation volume from 10.43 +/- 3.76 ml to 2.13 +/- 1.83 ml per beat (p < 0.05). No visual damage was observed on the mitral valve leaflets after 4 h of continuous operation. CONCLUSION: Based on the study results, the mitral web may represent a feasible option to repair different types of mitral valve prolapse. The mitral web may also significantly simplify mitral valve repair for complex lesions.
Ersin Erek; Muralidhar Padala; Kerem Pekkan; Jorge Jimenez; Yusuf K Yalçinba; Ece Salihoğlu; Tayyar Sarioğlu; Ajit P Yoganathan
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  18     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-29     Completed Date:  2009-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  300-6     Citation Subset:  IM    
Department of Cardiovascular Surgery, Acibadem Hospital, Istanbul, Turkey.
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MeSH Terms
Cardiac Surgical Procedures / instrumentation*,  methods
Equipment Design / trends*
Equipment and Supplies*
Hemodynamics / physiology
Mitral Valve / physiopathology,  surgery*
Mitral Valve Insufficiency / etiology,  surgery*
Mitral Valve Prolapse / complications,  surgery*
Models, Anatomic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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