Document Detail


Mitral valve surgery for heart failure: a failed innovation?
MedLine Citation:
PMID:  17157234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five million Americans suffer from heart failure. Despite innovative new pharmacologic and device therapy, the 5-year mortality rate for these patients remains near 50%. Conservatively, 300,000 patients with heart failure also have severe functional mitral regurgitation. Over the past decade the surgical approach to these patients has become more aggressive as the extent of the problem has become widely recognized and surgeon familiarity with annuloplasty techniques has increased. There are, however, few data to support that such interventions improve longevity, reduce heart size, or limit symptoms. In fact the best available data support the conclusion that surgery for functional mitral regurgitation has no effect on survival. We present a review of the existing data on the efficacy of mitral valve surgery in heart failure patients. These data are sobering but confirm the need for evidence-based decision-making in cardiac surgery no matter how intuitively beneficial a procedure may initially seem.
Authors:
Joseph H Gorman; Robert C Gorman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in thoracic and cardiovascular surgery     Volume:  18     ISSN:  1043-0679     ISO Abbreviation:  Semin. Thorac. Cardiovasc. Surg.     Publication Date:  2006  
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-27     Revised Date:  2013-09-09    
Medline Journal Info:
Nlm Unique ID:  8917640     Medline TA:  Semin Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-8     Citation Subset:  IM    
Affiliation:
Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
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MeSH Terms
Descriptor/Qualifier:
Comorbidity
Disease Progression
Heart Failure / epidemiology*,  mortality
Humans
Mitral Valve / surgery*
Mitral Valve Insufficiency / epidemiology*,  surgery*
Survival Analysis
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
HL63954/HL/NHLBI NIH HHS; HL73021/HL/NHLBI NIH HHS; R01 HL063954/HL/NHLBI NIH HHS; R01 HL071137/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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