Document Detail

Mitral valve repair for functional mitral regurgitation in end-stage dilated cardiomyopathy: role of the "edge-to-edge" technique.
MedLine Citation:
PMID:  16159854     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to assess the results of mitral valve (MV) repair in functional mitral regurgitation because of end-stage dilated cardiomyopathy (DCM). METHODS AND RESULTS: Seventy-seven patients with end-stage idiopathic (26 patients) or ischemic (51 patients) DCM underwent MV repair for functional mitral regurgitation (3 to 4+/4+). Fifty-eight patients (75.3%) were in New York Heart Association class III, and 19 (24.6%) were in IV. In 23 patients (29.8%) with a coaptation depth <1 cm, an isolated undersized annuloplasty was used. In the remaining 54 (70.1%), with a coaptation depth > or =1 cm, the "edge-to-edge" technique was associated with the annuloplasty. In most of the cases (88.3%), a complete rigid/semirigid ring was used. Concomitant coronary artery bypass graft was performed in 39 patients (50.6%). Hospital mortality was 3.8% (3 of 77). Actuarial survival was 90.7+/-3.64%, and freedom from cardiac events was 81.8+/-7.96% at 2.7 years. At a mean follow-up of 18.4+/-9.8 months (range, 1 month to 5 years) New York Heart Association class improved from 3.4+/-0.4 to 1.4+/-0.6 (P<0.0001). Mitral repair failure (recurrence of MR > or =3+/4+) was documented in 7 patients (9%): 2 in the edge-to-edge (2 of 54, 3.7%) and 5 in the isolated annuloplasty group (5 of 23, 21.7%) (P=0.03). Freedom from repair failure at 1.5 years was 95.0+/-3.4% and 77+/-12.1%, respectively (P=0.04). The absence of the edge-to-edge was the only predictor of repair failure (P=0.03). When residual MR was absent or mild, a reverse left ventricular remodeling was clearly documented. CONCLUSIONS: In patients with end-stage DCM, MV repair is feasible with low hospital mortality and important symptomatic improvement. The association of the edge-to-edge technique to the undersized annuloplasty can significantly improve the durability of the repair.
Michele De Bonis; Elisabetta Lapenna; Giovanni La Canna; Eleonora Ficarra; Marco Pagliaro; Lucia Torracca; Francesco Maisano; Ottavio Alfieri
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Circulation     Volume:  112     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-14     Completed Date:  2006-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  I402-8     Citation Subset:  AIM; IM    
Cardiac Surgery Department, San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy.
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MeSH Terms
Cardiac Surgical Procedures / methods
Cardiomyopathy, Dilated / complications*
Coronary Artery Bypass
Coronary Disease / complications,  surgery
Disease-Free Survival
Echocardiography, Stress
Heart Failure / etiology,  surgery
Hospital Mortality
Intra-Aortic Balloon Pumping / utilization
Life Tables
Middle Aged
Mitral Valve / surgery*
Mitral Valve Insufficiency / etiology,  surgery*,  ultrasonography
Postoperative Complications / epidemiology
Prospective Studies
Prostheses and Implants
Severity of Illness Index
Survival Analysis
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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