Document Detail

Mitral valve prolapse: now you see it; now you don't: recalling the discovery, rise and decline of a diagnosis.
MedLine Citation:
PMID:  17196476     Owner:  NLM     Status:  MEDLINE    
Mitral valve prolapse has been recognized as a clinical entity for only the past 50 years, although the auscultatory findings of this condition had been recognized since the mid-19th century. On the evidence of only a few autopsies, it was concluded that the basis for these were pleuropericardial adhesions. Left ventricular angiographic studies performed in the 1960s clearly documented the true nature of the condition, although it was not until the advent of echocardiography that large numbers of patients began to be referred for evaluation by this new technique. Because of the wide variety of symptoms in patients with suspected mitral valve prolapse, similar to those with other conditions, many patients with the latter were referred for evaluation and diagnosed with mitral valve prolapse because of misleading M-mode and then 2-dimensional criteria. It is now recognized, with the use of improved, more restrictive echocardiographic criteria, that the prevalence of the disorder is much less than previously believed. No test has been devised that will prove 100% sensitive and 100% specific for any disorder. In conclusion, this sobering fact should encourage the use of all modalities available, including clinical skills, to make proper diagnoses when these may be in doubt.
Allen B Weisse
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Publication Detail:
Type:  Historical Article; Journal Article     Date:  2006-11-13
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-02-08     Revised Date:  2007-06-05    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  AIM; IM    
New Jersey Medical School, Springfield, NJ, USA.
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MeSH Terms
Diagnostic Techniques, Cardiovascular / history*
History, 19th Century
History, 20th Century
Mitral Valve Prolapse / history*,  radiography,  ultrasonography
Comment In:
Am J Cardiol. 2007 May 1;99(9):1350   [PMID:  17478170 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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