Document Detail


Mitral valve prolapse in patients with prior rheumatic fever.
MedLine Citation:
PMID:  3349583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is known that rheumatic heart disease frequently results in isolated mitral regurgitation without concomitant mitral stenosis, especially in countries with a high prevalence of rheumatic fever. However, more recent surgical pathologic data also have demonstrated a high incidence of mitral valve prolapse in cases of rheumatic heart disease, which suggests that rheumatic fever may be a cause of mitral valve prolapse. To determine whether this association of mitral valve prolapse and rheumatic heart disease is present in a stable clinic population, we studied 30 patients who had an apical systolic murmur and a well-documented history of rheumatic fever with dynamic auscultation, two-dimensional echocardiography, and pulsed Doppler examinations. Twenty of the 30 patients (67%) had findings on physical examination consistent with isolated mitral regurgitation and 25 patients (84%) had mitral regurgitation by Doppler examination. Echocardiography demonstrated mitral valve prolapse in 24 patients (80%), whereas only one of the total study group had echocardiographic findings consistent with mitral stenosis. We conclude that (1) the presence of an isolated systolic murmur in patients with a history of rheumatic fever frequently represents pure mitral regurgitation secondary to mitral valve prolapse and (2) postinflammatory changes in valvular tissue resulting from rheumatic fever may be the etiology of mitral valve prolapse in these patients.
Authors:
N J Lembo; L J Dell'Italia; M H Crawford; J F Miller; K L Richards; R A O'Rourke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  77     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-04-28     Completed Date:  1988-04-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  830-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Texas Health Science Center, San Antonio.
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MeSH Terms
Descriptor/Qualifier:
Adult
Echocardiography
Female
Heart Auscultation
Humans
Male
Middle Aged
Mitral Valve Insufficiency / diagnosis,  etiology
Mitral Valve Prolapse / diagnosis,  etiology*
Rheumatic Heart Disease / diagnosis*
Grant Support
ID/Acronym/Agency:
T32-HL07350/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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