Document Detail

Mitral valve prolapse in one hundred presumably healthy young females.
MedLine Citation:
PMID:  1248078     Owner:  NLM     Status:  MEDLINE    
Clinical, electrocardiographic, phonocardiographic, and echocardiographic examinations were performed in 100 presumably healthy young females. Treadmill testing and ambulatory electrocardiographic monitoring were performed in a selected group of these subjects. Phonocardiograms, recorded with the subjects supine at rest, after inhalation of amyl nitrite, and in the upright position, revealed a 17% incidence of nonejection clicks and/or late or mid- to late systolic murmurs (PHONO-MSCLSM). Echocardiographic studies were performed in the second, third, fourth, and fifth intercostal space with emphasis on the importance of transducer angulation on the chest. Studies obtained with the transducer perpendicular to the chest in the sagittal plane, or pointing cephalad at a time when both mitral leaflets and left atrium are recorded, are optimal to study the mitral valve systolic motion. With the transducer in this position, 21 subjects were found to have pansystolic or late systolic prolapse, as previously defined on the echocardiogram. The presence of these echocardiographic findings was statistically related to the presence of PHONO-MSCLSM. Other echocardiographic patterns were identified and their relation to PHONO-MSCLSM and transducer position is discussed. Ten subjects with both echocardiographic evidence of mitral valve prolapse and PHONO-MSCLSM were identified (group EP), while 18 other subjects had either echocardiographic or phonocardiographic findings suggestive of mitral valve abnormality (group EorP). Seventy-two subjects had no abnormality (group noEP). The incidence of various clinical, electrocardiographic, and echocardiographic findings in these three groups was determined. Some findings said to be common in patients with proven mitral valve prolapse were seen more frequently in group EP subjects. Echocardiographic and phonocardiographic findings suggesting mitral valve abnormalities were found more commonly than expected in a population of presumably healthy young females.
W Markiewicz; J Stoner; E London; S A Hunt; R L Popp
Related Documents :
11229218 - Usefulness of echocardiography in detection of subclinical carditis in acute rheumatic ...
24350078 - Leaking heart: ticking time bomb!
21427628 - Impact of n-acetylcysteine on neonatal cardiomyocyte ischemia-reperfusion injury.
9343038 - Lupus-related mitral valve disease: embolic coronary occlusion as a unique cause of myo...
16076278 - Assessment of cardiac function by electron-beam computed tomography.
8869068 - Treatment of chronic unstable angina pectoris: use of a totally implantable programmabl...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  53     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-04-30     Completed Date:  1976-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-73     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Exercise Test
Heart Murmurs
Mitral Valve / physiopathology
Mitral Valve Insufficiency / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrophysiological and clinical observations in patients with alternating bundle branch block.
Next Document:  Spectrum of echocardiographic findings in bacterial endocarditis.