Document Detail

Mitral valve prolapse, aortic compliance, and skin collagen in joint hypermobility syndrome.
MedLine Citation:
PMID:  3902069     Owner:  NLM     Status:  MEDLINE    
Mitral valve prolapse was sought clinically and with phonocardiography and M mode and sector echocardiography in 15 women aged 22-57 years with joint hypermobility syndrome. The type III:III + I collagen ratio was measured in skin biopsy specimens and was found to be raised in seven of 10 patients sampled. Thirteen patients had increased aortic wall compliance measured by the continuous wave Doppler ultrasound technique. Ten (67%) patients had mitral valve prolapse shown by auscultatory signs or echocardiography or both--a prevalence at least three times greater than that in the general adult population. It is concluded that if the abnormality of collagen biosynthesis found in skin biopsy samples in these patients is also present in their mitral valve tissue this may predispose them to prolapse of the valve.
C E Handler; A Child; N D Light; D E Dorrance
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British heart journal     Volume:  54     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-20     Completed Date:  1985-12-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-8     Citation Subset:  AIM; IM    
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MeSH Terms
Aorta / physiopathology*
Collagen / analysis*
Joint Instability / complications*,  metabolism,  physiopathology
Middle Aged
Mitral Valve Prolapse / complications*,  metabolism,  physiopathology
Skin / ultrastructure
Reg. No./Substance:

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