Document Detail


Mitral valve motion assessed by high-speed video camera in isolated swine heart.
MedLine Citation:
PMID:  16949829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We have recently reported our isolated and working swine heart model that examines the valve motion precisely by a high-speed digital video camera system. Using this modality, the present study aimed (1) to delineate the motion of the mitral leaflets, chords and annulus throughout the cardiac cycle, and (2) to elucidate the influence of alterations in loading conditions on leaflet excursion. METHODS: The valve motion of five isolated and working swine hearts was observed by an endoscope recording the images at 250 frames per second. Modified Krebs-Ringer solution was used as the sole perfusate. The images were obtained in hearts 30 min after reperfusion, changing the left atrial pressure as 4, 8, and 12 mmHg. RESULTS: The motion of the mitral valve in the vicinity of diastole was considered to be well understood by dividing the entire sequence into five stages: 'decoaptation,' 'E excursion,' 'diastasis,' 'A excursion,' and 'coaptation.' Initial separation occurred at both sides of the central tips of the leaflets. The leading edges always followed the mid-portion of the rough zone during opening and closing. The 'strut' second-order chords retained their tension throughout the cardiac cycle and played the role as rotary shafts of the other branching chords. The first-order chords lost their tension during opening, suggesting they mainly are involved in valve competence. Annular constriction occurred coincident with atrial contraction. An increase in preload made the isovolumic relaxation and contraction times shorter. The leaflets opened faster in the rapid-filling phase, whereas they required more time for opening and closing in the atrial-filling phase. CONCLUSIONS: The present study revealed the integrated movement of the mitral leaflets, chords and annulus, as well as the impact of altered preload.
Authors:
Shunei Saito; Yoshimori Araki; Akihiko Usui; Toshiaki Akita; Hideki Oshima; Jun Yokote; Yuichi Ueda
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Publication Detail:
Type:  Journal Article     Date:  2006-09-01
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  30     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-14     Completed Date:  2007-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  584-91     Citation Subset:  IM    
Affiliation:
Department of Cardiothoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. shunei@med.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Diastole
Mitral Valve / physiology*
Models, Animal
Movement
Myocardial Contraction / physiology*
Perfusion
Swine
Systole
Thoracoscopes*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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