Document Detail

Mitral valve hemorrhage and mitral annulus shrinkage in rabbits with transient ventricular bigeminies induced by vagal stimulation.
MedLine Citation:
PMID:  15473479     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM OF THE STUDY: Cervical vagal stimulation in rabbits frequently induces transient ventricular bigeminies, followed by mitral regurgitation lasting a few days, and development of peculiar lesions of the mitral complex. The present study investigated early lesions of the mitral valve and subsequent deformation of the mitral annulus associated with ventricular bigeminies in this animal model METHODS: A 1-min period of right cervical vagal electrical stimulation was repeated in anesthetized rabbits under ECG monitoring. Animals were sacrificed at 1 h after stimulation to investigate early mitral valve lesions (n = 71; group A), or after one week for measurement of mitral annulus area, using photographic planimetry (n = 56; group B). RESULTS: Ventricular bigeminies were recorded during vagal stimulation in 72% of group A (n = 51), and 73% of group B (n = 41). The most prominent early mitral valve lesion comprised widespread punctate hemorrhages over the chordae and leaflets, which developed in most animals with ventricular bigeminies (88%), but rarely in those without ventricular bigeminies (5%). This inter-group difference was highly significant (p <0.001). Gross examinations performed at one week after vagal stimulation revealed a deformed mitral annulus resulting from stiff, edematous periannular myocardial tissues. Animals with ventricular bigeminies displayed a significantly smaller mitral annulus area than those without ventricular bigeminies (26.8 +/- 1.0 versus 31.7 +/- 1.2 mm2; p <0.01). CONCLUSION: Early mitral valve hemorrhage and later mitral annulus shrinkage occur following vagus-induced transient ventricular bigeminies. This may result from unusual mechanical stress on the mitral complex secondary to distorted ventricular contraction in the context of ventricular bigeminies.
Terunao Ashida; Chikako Ono; Takao Sugiyama; Jun Fujii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  13     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2004-11-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  779-83     Citation Subset:  IM    
Division of Cardiovascular Diseases, The Institute for Adult Diseases Asahi Life Foundation, Tokyo, Japan.
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MeSH Terms
Arrhythmias, Cardiac / etiology,  physiopathology*
Body Weights and Measures
Electric Stimulation / adverse effects
Heart Valve Diseases / etiology,  pathology*
Heart Ventricles / pathology*,  physiopathology
Hemorrhage / etiology,  pathology*
Mitral Valve / pathology
Vagus Nerve*

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